Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis
Our data demonstrate that Optn overexpression protects MNs, inhibites cellular apoptosis, improves mitochondrial quality and regulates neuroinflamation in SOD1 <sup><i>G</i>93<i>A</i></sup> mice at the pre-symptomatic stage.
Authors
- Yi An (ORCID: https://orcid.org/0009-0000-0947-2379)
- Xue Bai (ORCID: https://orcid.org/0000-0003-2309-521X)
- Fei Yang (ORCID: https://orcid.org/0000-0003-3074-6973)
- Yali Zhang (ORCID: https://orcid.org/0009-0009-7910-5430)
- Cheng Ma (ORCID: https://orcid.org/0000-0002-9767-8066)
- Yanchao Lu
- Shumin Zhao
- Jingjing Zhang (ORCID: https://orcid.org/0000-0002-2655-0428)
- Ying Gao (ORCID: https://orcid.org/0000-0002-2981-9269)
- Ranran Chen (ORCID: https://orcid.org/0000-0003-3216-2373)
Institutions
- Chifeng University (CN)
- Chifeng Municipal Hospital (CN)
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-02-07
- DOI
- https://doi.org/10.3389/fnagi.2025.1522073
- Citations
- 3
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- Inner Mongolia Medical University
- National Natural Science Foundation of China
- Natural Science Foundation of Inner Mongolia