Development of the early fetal human thalamus: from a protomap to emergent thalamic nuclei
In human discrete thalamic nuclei exhibiting discrete gene expression patterns emerge relatively early from a protomap of gene expression. The migration of GABAergic neurons into the thalamus occurs over a protracted period, first from the midbrain. Disruption of CNTNAP2 activity and function could be hypothezised to have a variety of effects upon thalamic development.
Authors
- Charles Jeffrey Smith (ORCID: https://orcid.org/0000-0001-7330-4185)
- Susan Lindsay (ORCID: https://orcid.org/0000-0003-2980-4582)
- Niveditha Sankar
- Ross Laws (ORCID: https://orcid.org/0000-0003-3241-2344)
- Ayman Alzu’bi
- Gavin J. Clowry (ORCID: https://orcid.org/0000-0002-6489-8329)
- Maznah Alhesain
- Janet Kerwin (ORCID: https://orcid.org/0009-0006-5163-2405)
Institutions
- Newcastle University (GB)
- Yarmouk University (JO)
Publication Details
- Journal
- Frontiers in Neuroanatomy
- Published
- 2025-02-07
- DOI
- https://doi.org/10.3389/fnana.2025.1530236
- Citations
- 2
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.63
Funders
- Wellcome Trust
- Yarmouk University
- Medical Research Council