The role of natural exosomes from SHED-MSC in immunoregulation of M0/M1 polarized macrophage cells
The findings suggest that exosomes derived from SHED-MSC can skew M0/M1 macrophages to the M2 phenotype and inhibit M1 polarization. These nanovesicles, with their distinct physical properties and ability to penetrate target cells, may prove beneficial in conditions involving the depletion of M2 macrophages and M1 macrophage-induced diseases, potentially aiding in the reduction of inflammation and tissue injury.
Authors
- Mohsen Saeidi
- Ali Fallah (ORCID: https://orcid.org/0000-0002-2258-3070)
- Ayyoob Khosravi (ORCID: https://orcid.org/0000-0003-2340-1870)
- Abasalt Hosseinzadeh Colagar (ORCID: https://orcid.org/0000-0001-6536-8250)
- Azadeh Mohammad‐Hasani
Institutions
- Golestan University (IR)
- Golestan University of Medical Sciences (IR)
- University of Mazandaran (IR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1550280
- Citations
- 12
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 9.67