Bradykinin B1 receptor signaling triggers complement activation on endothelial cells
This study demonstrates that KKS activation contributes to complement activation on the endothelium by B1R signaling. Blocking the B1R may have a role in reducing complement deposition and its effects on the endothelium.
Authors
- Alexandra Gerogianni (ORCID: https://orcid.org/0000-0002-6194-6903)
- Ingrid Lopatko Fagerström
- Michael Bäder (ORCID: https://orcid.org/0000-0003-4780-4164)
- Fatimunnisa Qadri
- Diana Karpman (ORCID: https://orcid.org/0000-0001-7220-7658)
- Ashmita Tontanahal (ORCID: https://orcid.org/0000-0002-7504-2091)
- Ida Arvidsson
- Markus Wendler (ORCID: https://orcid.org/0009-0008-8293-745X)
- Ann‐Charlotte Kristoffersson
Institutions
- Lund University (SE)
- Max Delbrück Center (DE)
- German Centre for Cardiovascular Research (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1527065
- Citations
- 1
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Lunds Universitet
- IngaBritt och Arne Lundbergs Forskningsstiftelse
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Stiftelsen Frimurare Barnhuset i Stockholm
- Skånes universitetssjukhus