Uncovering the antidepressant active ingredients and related molecular mechanisms of Xiaoyao Pill using integrated pharmacological strategy
These findings suggested that XYP may exert antidepressant effects through atractylenolide III, paeoniflorin, saikosaponin D, liquiritin, formononetin, affecting the PIK3/AKT signaling pathway. This lays the foundation for the research on the quality standards and clinical rational application of traditional Chinese medicine formulas.
Authors
- Hongping Long (ORCID: https://orcid.org/0000-0001-8891-5851)
- Pan Meng
- Siqian Zhou
- Jing Li (ORCID: https://orcid.org/0000-0002-0319-9700)
- Juan Wu (ORCID: https://orcid.org/0000-0003-0286-1704)
- Xie Mingxia
- Lin Jiang
- Yajing Wang (ORCID: https://orcid.org/0000-0002-3605-8437)
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Chromatography B
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1016/j.jchromb.2025.124502
- Citations
- 3
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 4.67
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province
- Scientific Research Foundation of Hunan Provincial Education Department