Identifying macrophage-associated subtypes in patients with serous ovarian cancer and exploring potential personalized therapeutic drugs using combined single-cell and bulk RNA sequencing omics
We identified specific M1 and M2 macrophage markers and found potential therapeutic compounds (dasatinib and afatinib) in these specific markers. These potential therapeutic compounds provide insight into the underlying mechanisms of serous ovarian cancer (OC) and inspire more effective treatment methods.
Authors
- Ke Miao (ORCID: https://orcid.org/0000-0003-4018-2446)
- Dehong Che
- Fei Teng (ORCID: https://orcid.org/0000-0001-9076-8862)
- Xiaoqiu Dong (ORCID: https://orcid.org/0000-0002-3064-0290)
- Hong Wei (ORCID: https://orcid.org/0000-0003-0822-0457)
Institutions
- Harbin Medical University (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.heliyon.2025.e42429
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Harbin Medical University
- Natural Science Foundation of Heilongjiang Province