Knudson’s “Two-Hit” Hypothesis and Cancer Predisposition: A Bit More Complicated but Still Going Strong
This study by Treger and colleagues is a comprehensive evaluation of the genome and epigenome of tumors and constitutional tissue from children with Wilms tumor predisposition syndromes that demonstrates that the molecular features of Wilms tumors are dependent on the constitutional milieu of the patient in which they develop. See related article by Treger et al., p. 286.
Authors
- Jack Brzezinski (ORCID: https://orcid.org/0000-0002-9475-0077)
- David M. Malkin (ORCID: https://orcid.org/0000-0001-5752-9763)
Institutions
- University of Toronto (CA)
- Hospital for Sick Children (CA)
- Fred Hutch Cancer Center (US)
- Seattle Children's Hospital (US)
- Center for Cancer and Blood Disorders (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-1662
- Citations
- 2
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 1.61