Huang-qin decoction increases the sensitivity of EGFR-TKIs to NSCLC cells by regulating stat3/GPX4 to induce redox ratio and ROS to inhibit CSCs
HQD enhances the anti-cancer effect of EGFR-TKIs in NSCLC through ROS-mediated CSC makers inhibition by suppressing stat3/GPX4 axis to induce redox ratio, providing a novel strategy for the treatment of NSCLC patients.
Authors
- Zhenzhen Xiao
- Yanan Li (ORCID: https://orcid.org/0000-0002-1868-3626)
- Yan-juan Zhu (ORCID: https://orcid.org/0000-0002-1956-7774)
- Yisheng Su (ORCID: https://orcid.org/0000-0001-9479-6561)
- Qing Tang (ORCID: https://orcid.org/0000-0002-2128-4810)
- Changju Ma (ORCID: https://orcid.org/0000-0001-9055-7272)
- Haibo Zhang (ORCID: https://orcid.org/0000-0001-8104-4280)
- Ling Han (ORCID: https://orcid.org/0000-0002-6168-8828)
- Ruidi Jiang
- Yaya Yu (ORCID: https://orcid.org/0000-0002-7309-7347)
- Yadong Chen (ORCID: https://orcid.org/0000-0003-1945-5403)
- Chenjing Lei
- Lina Ding
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Guangdong Pharmaceutical University (CN)
Publication Details
- Journal
- Journal of Traditional and Complementary Medicine
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1016/j.jtcme.2025.02.004
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00