Chest Discomfort, Left Ventricular Hypertrophy, Global T‐Wave Inversion, and Short <scp>PR</scp> Interval Points to a Particular Cardiac Condition. What Could Be the Diagnosis?
This article describes a 44-year-old female with Fabry disease presenting with a 7-year history of chest discomfort, extremity pain, and hypohidrosis. ECG revealed sinus bradycardia (52 bpm), a short PR interval (100 ms) with a delta wave, and a QRS complex (126 ms) showing a complete right bundle branch block. T-wave inversion and ST-segment depression were observed in leads I, AVL, II, aVF, and V2-V6. Genetic testing confirmed Fabry disease (GLA: c.700_702del). Short PR interval with left ventricular hypertrophy (LVH) poses a diagnostic challenge, requiring advanced imaging and genetic testing to differentiate Fabry disease from other cardiomyopathies.
Authors
- Xinxin Di
- Jing‐Xiu Li (ORCID: https://orcid.org/0000-0003-0291-8176)
- Min Gao (ORCID: https://orcid.org/0000-0002-7263-1157)
- Yanlin Wang (ORCID: https://orcid.org/0000-0003-2639-6536)
- Jie Zheng (ORCID: https://orcid.org/0009-0005-6312-7433)
- Xue‐Qi Li
Institutions
- University of Science and Technology of China (CN)
- Harbin Medical University (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Annals of Noninvasive Electrocardiology
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1111/anec.70048
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Aerospace Center Hospital