Refining the adriamycin‐induced focal segmental glomerulosclerosis mouse model to improve reproducibility and animal welfare
Based on the outcome from this study, we identified the optimal ADR dosing level and model testing duration. A standard operating procedure (SOP) for the ADR-induced FSGS mouse model was established to facilitate FSGS basic research and drug development.
Authors
- Troy J. Plumb (ORCID: https://orcid.org/0000-0002-8517-0070)
- Hui‐di Jiang (ORCID: https://orcid.org/0000-0002-7678-7992)
- Zhenshan Jia (ORCID: https://orcid.org/0000-0002-9910-9860)
- Geoffrey M. Thiele (ORCID: https://orcid.org/0000-0001-5688-8596)
- Kirk Foster
- S.A. Al-Thobaiti
- Braeden Pinkerton
- Dong Wang (ORCID: https://orcid.org/0000-0002-8340-2763)
- Xin Fu (ORCID: https://orcid.org/0000-0001-8473-5079)
Institutions
- Nebraska Medical Center (US)
- VA Nebraska Western Iowa Health Care System (US)
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- Animal Models and Experimental Medicine
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1002/ame2.12564
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Congressionally Directed Medical Research Programs