What Drug-based Blood-sparing Strategy for Total Hip Replacement (THR) Surgery at the University Hospital Center (CHU) de la Renaissance in Chad?

Total hip replacement (THR) surgery is an operation with a high bleeding potential. It is performed regularly at the University Hospital Center (CHU) of N'Djamena. To overcome the difficulties of blood supply and minimize the infectious risks that can result from blood transfusion. We paid particular attention to carrying out a prospective epidemiological study of the blood-sparing strategy, using drugs such as tranexamic acid (ATX) and iron. We enrolled 44 patients during our 13-month study period from November 1, 2022 to December 31, 2023. 47.73% (n=21) of patients received a dose of 1g of ATX in 30 min before incision and 500mg at the end of the procedure, 25% (n=11) received a dose of 500mg before incision and 500mg/6h/24h and 11.36% received 1g only at incision. Blood loss was greater in the non-ATX group, with P-value above the confidence level (0.32 > 0.05). Thus, through this study and the various studies carried out on the subject [4, 6-10], we were able to observe that the use of the combination of tranexamic acid and iron proves effective for the blood-sparing strategy during THP surgery.