The Production of Benzothiazoles in an Organic Solvent DMF Catalyzed by Baker's Yeast

Benzothiazoles are an important class of privileged organic compounds of medicinal significance due to their recognized biological and therapeutic activities. As such, these heterocycles constitute key structural motifs that exhibit a wide range of biological properties. Benzothiazoles are bicyclic ring systems. In the 1950s, a number of benzothiazoles were intensively studied as central muscle relaxants. Since then medicinal chemists have not taken active interest in this chemical family. Biologist?s attention was drawn to this series when the pharmacological profile of Riluzole was discovered. Riluzole is a drug used to treat amyotrophic lateral sclerosis. After that, benzothiazole derivatives have been studied extensively and found to have diverse chemical reactivity and broad spectrum of biological activities.1 A large number of therapeutic agents are synthesized with the help of benzothiazole nucleus. During recent years there have been some interesting developments in the biological activities of benzothiazole derivatives. These compounds have special significance in the field of medicinal chemistry due to their remarkable pharmacological potentialities.2 The 2 - Substitued benzothiazole has emerged in its usage as a core structure in the diversified therapeutic applications. The studies of structure?activity relationship interestingly reveal that change of the structure of substituent group at C - 2 position commonly results the change in its bioactivity. It shows different properties like Anti - cancer3 - 4, Anti - bacterial5, 6, 7, Anti - tuberculosis8, Anti - diabetic, Anti - inflammatory9 - 12, Anti - viral, Anti - oxidant13 - 15. In the present work an efficient and cost effective synthetic protocol have been developed for 2 - arylbenzothiazoles using milder reaction conditions, carrying the condensation of 2 - aminothiophenols and aryl aldehydes in organic solvent medium like DMF inpresence of active dry baker?s yeast.