Exogenous cystine increases susceptibility of drug-resistant Salmonella to gentamicin by promoting oxidation of glutathione metabolism and imbalance of intracellular redox levels

This study confirms that cystine enhances the antimicrobial efficacy of gentamicin against drug-resistant <i>Salmonella</i>. Through the application of metabolomics, the underlying metabolic mechanisms by which cystine exerts its effects on <i>Salmonella</i> have been elucidated, offering a novel perspective in the domain of metabolic reprogramming aimed at counteracting drug resistance. Furthermore, these findings reinforce the potential role of small-molecule metabolites as effective adjuvants to enhance antibiotic action.