An Assessment of BHLHE40 Transcription Factor Level and its Target Cytokines in Patients with Rheumatoid Arthritis

Evaluation of the expression level of <i>BHLHE40</i> in RA patients showed a significant increase. In line with the elevated level of BHLHE40, a significant increase in the expression level of <i>IL</i>-17 and <i>IFN</i>-γ was also detected. These findings point to the possible role of BHLHE40 in the disease course or severity by elevating the levels of inflammatory cytokines, including IL-17 and <i>IFN</i>-γ. Therefore, BHLHE40 might be considered either as a putative biomarker or as a candidate for therapy in a variety of human diseases.