Malignant phyllodes tumors with sarcomatous components: A histopathologic and molecular study
The presence of an osteosarcoma component may serve as an indicator for unfavorable prognosis. Activating mutations in TP53 have been identified in these tumors. Furthermore, it typically facilitates tumor formation and progression via the NOTCH signaling pathway. These findings may offer valuable insights for clinical prognosis and identify potential therapeutic targets.
Authors
- Cunyan Xia
- Yan Peng (ORCID: https://orcid.org/0000-0001-9972-9640)
- Wenyue Da
- Qing Li (ORCID: https://orcid.org/0000-0003-4661-3681)
- Xue Song (ORCID: https://orcid.org/0000-0002-9305-9161)
- Ting Lei
- Yongqiang Shi
- Zhiyi Shen
- Xu Deng
Institutions
- Soochow University (CN)
- Simcere Pharmaceutical (China) (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1016/j.tranon.2025.102318
- Citations
- 2
- Primary Topic
- Metastasis and carcinoma case studies
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Youth and Middle-aged Scientific and Technological Innovation Leading Talents Program of the Corps