Therapeutic Mechanism of Zhishi Decoction Regulating P38/MAPK Signaling Pathway on Functional Constipation (FC)
This study confirmed that ZSD could act on AKT1, MAPK12, and MAPK14 targets to activate the p38/MAPK signaling pathway to relieve FC induced by defenoxate tablets. The further development of ZSD provided a theoretical basis.
Authors
- Yang Xu
- Nan Sui (ORCID: https://orcid.org/0000-0002-3327-3174)
- Jie Kang (ORCID: https://orcid.org/0009-0005-0425-0829)
Institutions
- Liaoning University of Traditional Chinese Medicine (CN)
- General Hospital of Shenyang Military Region (CN)
- Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2025-02-07
- DOI
- https://doi.org/10.2174/0113862073332162241126105559
- Citations
- 1
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 1.56