TWIST1 regulates HK2 ubiquitination degradation to promote pancreatic cancer invasion and metastasis
This study demonstrates that TWIST1 regulates the ubiquitination and degradation of HK2, thereby promoting glycolysis-induced cuproptosis and facilitating pancreatic cancer invasion and metastasis. Understanding the underlying mechanisms of PDAC, including the regulation of key proteins such as HK2 by TWIST1, is crucial for developing more effective treatment strategies. Findings highlight the importance of targeting these molecular pathways, which could lead to improved diagnostic and therapeutic approaches, ultimately enhancing patient outcomes and prognosis.
Authors
- Mingze Ma (ORCID: https://orcid.org/0000-0002-6706-7483)
- Ruxin Gao (ORCID: https://orcid.org/0009-0006-0596-4898)
- Shuai Shao (ORCID: https://orcid.org/0000-0001-6941-8913)
- Xinxing Wang (ORCID: https://orcid.org/0000-0003-1650-3297)
- Xianwen Xu
- Chuan Qin (ORCID: https://orcid.org/0009-0002-0250-6630)
- Zhenhai Zhang (ORCID: https://orcid.org/0000-0002-4479-7205)
Institutions
- Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s12935-024-03583-z
- Citations
- 4
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- CIEE Ping Foundation
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province