Anti-xa guided enoxaparin thromboprophylaxis is associated with less thromboembolism than fixed dose dalteparin in trauma patients admitted to intensive care
Among adult patients in the trauma ICU, compared to a fixed dose dalteparin, enoxaparin prophylaxis with dose calibration according to peak anti-Xa levels was associated with lower VTE rates without increasing the risk of bleeding. About 40% of patients who received initial enoxaparin doses of 30 mg twice daily had anti-Xa levels suggestive of inadequate prophylaxis. Calibrating LMWH dosing may improve VTEp following traumatic injury.
Authors
- Ahad Kanbar (ORCID: https://orcid.org/0000-0001-5882-9055)
- Ayman El‐Menyar (ORCID: https://orcid.org/0000-0003-2584-953X)
- Ahmad Kloub
- Sandro Rizoli (ORCID: https://orcid.org/0000-0001-8250-7355)
- Hassan Al‐Thani (ORCID: https://orcid.org/0000-0001-9102-9033)
- Abubaker Al-Aieb
- Fajer Al‐Ishaq
- Naushad Ahmad Khan (ORCID: https://orcid.org/0000-0002-6961-8816)
- Mohammad Asim (ORCID: https://orcid.org/0000-0002-2074-5929)
- Suha Abumusa
- Yazan Hinawi
- Tarik Abulkhair (ORCID: https://orcid.org/0000-0001-8048-1390)
Institutions
- Weill Cornell Medical College in Qatar (QA)
- Hamad Medical Corporation (QA)
Publication Details
- Journal
- European Journal of Trauma and Emergency Surgery
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1007/s00068-025-02768-z
- Citations
- 2
- Primary Topic
- Venous Thromboembolism Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- Hamad Medical Corporation
- Medical Research Council