Analysis of prenatal diagnosis and pregnancy outcomes for rare autosomal trisomies detected by non-invasive prenatal testing in 33,079 cases
Prenatal diagnosis for high-risk rare autosomal trisomies typically reveals a normal karyotype with no detectable chromosomal abnormalities, and most cases can achieve full-term pregnancy outcomes. However, adverse pregnancy outcomes such as preterm birth, fetal demise, placental abnormalities, and intrauterine growth restriction are common and should be given clinical attention and consideration.
Authors
- Shuai Zhang (ORCID: https://orcid.org/0000-0001-9601-6717)
- Peng Haiying (ORCID: https://orcid.org/0009-0005-2069-3777)
- Ying Zhang
- Kai Ding (ORCID: https://orcid.org/0009-0008-4304-4333)
- Yan Xu (ORCID: https://orcid.org/0000-0002-8469-6476)
- Xin Zhang (ORCID: https://orcid.org/0000-0001-6036-2685)
Institutions
- Hubei University of Medicine (CN)
- Cell Technology (China) (HK)
- People's Hospital of Shiyan (CN)
Publication Details
- Journal
- BMC Medical Genomics
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s12920-025-02099-3
- Citations
- 3
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 10.48
Funders
- Hubei University of Medicine
- Hubei University