Comparison of phenotypic and genetic traits of ESBL-producing UPEC strains causing recurrent or single episode UTI in postmenopausal women
Our findings indicate strain-specific ability to persist inside BECs with the recurrent strains exhibiting increased ompT expression inside BECs and higher intracellular bacterial burden compared to strains causing single episode UTI. These results emphasize the potential microbial contributions to recurrence in postmenopausal women and warrant future investigations on the impact of antibiotic therapy and host response on IBC-supportive UPEC virulence.
Authors
- Annie Wong‐Beringer (ORCID: https://orcid.org/0000-0003-3302-1409)
- Peter Jorth (ORCID: https://orcid.org/0000-0002-0981-740X)
- Michelle Kalu (ORCID: https://orcid.org/0000-0002-6990-0125)
Institutions
- University of Southern California (US)
- Cedars-Sinai Medical Center (US)
Publication Details
- Journal
- Annals of Clinical Microbiology and Antimicrobials
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s12941-025-00779-7
- Citations
- 1
- Primary Topic
- Urinary Tract Infections Management
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Merck