β-synuclein in cerebrospinal fluid as a potential biomarker for distinguishing human prion diseases from Alzheimer’s and Parkinson’s disease
Our data here indicate that CSF β-syn is a potential biomarker for distinguishing PrDs (gCJD, sCJD and GSS) from AD and PD, but is much less efficient from VE and AE. These findings have critical implications for early diagnosis and monitoring of synaptic integrity in prion diseases.
Authors
- A Ruhan
- Bing Xu (ORCID: https://orcid.org/0009-0006-6893-5226)
- Liping Gao (ORCID: https://orcid.org/0000-0002-7022-0418)
- Kang Xiao (ORCID: https://orcid.org/0000-0002-7666-2460)
- Cao Chen (ORCID: https://orcid.org/0000-0002-5193-9283)
- Xiao-Xi Jia
- Dong-Lin Liang
- Xiao‐Ping Dong (ORCID: https://orcid.org/0000-0002-1566-8447)
- Qi Shi (ORCID: https://orcid.org/0000-0002-6282-9864)
- Chunjie Li (ORCID: https://orcid.org/0000-0002-3287-2140)
- Rundong Cao
- Weiwei Zhang (ORCID: https://orcid.org/0000-0003-3258-5528)
Institutions
- Capital Medical University (CN)
- Chinese Academy of Sciences (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Wuhan Institute of Virology (CN)
- National Institute for Viral Disease Control and Prevention (CN)
- China Academy of Chinese Medical Sciences (CN)
- Beijing Friendship Hospital (CN)
- Shanghai Institute of Technology (CN)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s13195-025-01688-9
- Citations
- 4
- Primary Topic
- Prion Diseases and Protein Misfolding
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Chinese Center for Disease Control and Prevention
- Centers for Disease Control and Prevention
- State Key Laboratory of Infectious Disease Prevention and Control