Overexpression of metalloproteinase PAPPA accelerates cancer progression and correlates with immune cell infiltration in gastric cancer: insights from bioinformatics and in vitro investigations
The findings of this investigation suggest that PAPPA serves as a crucial modulator of GC, underscoring its potential as a GC treatment target.
Authors
- Huiyan Chen (ORCID: https://orcid.org/0009-0003-7464-3906)
- Hu Zhao
- Junhong Wu
- Jiong Chen (ORCID: https://orcid.org/0000-0001-9389-520X)
- Shiyao Zheng (ORCID: https://orcid.org/0009-0003-3555-1806)
- Yongyuan Chen (ORCID: https://orcid.org/0009-0005-2243-8438)
- Hongming Lin
- Shiya Yu
- Jianwei Chen (ORCID: https://orcid.org/0000-0002-5364-0058)
- Xiaojuan Yu (ORCID: https://orcid.org/0000-0002-3158-9028)
- Yu Wang (ORCID: https://orcid.org/0000-0002-3002-2425)
- Weihang Wu
- Jinwei Qiu
Institutions
- Fujian Medical University (CN)
- Fudan University (CN)
- 174th hospital of the People's Liberation Army (CN)
- Fuzhou General Hospital of Nanjing Military Command (CN)
- Fuzhou Second Hospital (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s12935-025-03650-z
- Citations
- 4
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.75
Funders
- Natural Science Foundation of Fujian Province