An undescribed jatrophane diterpenoid along with known compounds from <i>Euphorbia sororia</i> with tumour multidrug resistance reversal ability

An undescribed jatrophane diterpenoid, euphosorophane N (<b>1</b>), along with thirteen known jatrophane diterpenoids (<b>2-14</b>), were isolated from the fructus of <i>Euphorbia sororia</i>, and their chemical structures were elucidated based on extensive spectroscopic analysis, including HRESIMS, 1D and 2D NMR data. The X-ray crystallographic analysis was used to confirm the absolute configurations of compound <b>6</b> for the first time. These jatrophane diterpenoids were evaluated for their multidrug resistance (MDR) reversal ability on the cancer cell line HCT-8/Taxol by MTT assay and compounds <b>3</b>, <b>5</b>, and <b>9</b> revealed promising MDR reversal ability compared to verapamil (VRP).