SEOM-GEIS Spanish clinical guidelines for the management of soft‑tissue sarcomas (2024)

Soft-tissue sarcomas are rare, diverse malignant tumors of mesenchymal origin, requiring diagnosis and treatment by a specialized multidisciplinary team. Initial assessment includes radiology and biopsy, followed by wide surgical resection with clear margins for localized cases. Radiotherapy is recommended for large, deep, high-grade tumors or after incomplete resection, while perioperative chemotherapy may be considered for high-risk cases. In oligometastatic disease, combining local and systemic therapies is an option. Anthracycline-based chemotherapy is the first-line treatment in advanced disease, though other drugs show efficacy in certain subtypes. Given the limited options, enrolling in clinical trials is advised for patients needing further treatment.

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Publication Details

Journal
Clinical & Translational Oncology
Published
2025-02-07
DOI
https://doi.org/10.1007/s12094-024-03842-5
Primary Topic
Sarcoma Diagnosis and Treatment
Type
article
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article

SEOM-GEIS Spanish clinical guidelines for the management of soft‑tissue sarcomas (2024)

Nadia Hindi, Áurea Molina, Javier Martínez‐Trufero, Ana Paisán et al.
Clinical & Translational Oncology
Sarcoma Diagnosis and Treatment
article

SEOM-GEIS Spanish clinical guidelines for the management of soft‑tissue sarcomas (2024)

Nadia Hindi, Áurea Molina, Javier Martínez‐Trufero, Ana Paisán, Raúl Sánchez, César Serrano, María Ángeles Sala, Irene Carrasco, Jerónimo Martínez-García, M.A. Arregui
article en

Abstract

Soft-tissue sarcomas are rare, diverse malignant tumors of mesenchymal origin, requiring diagnosis and treatment by a specialized multidisciplinary team. Initial assessment includes radiology and biopsy, followed by wide surgical resection with clear margins for localized cases. Radiotherapy is recommended for large, deep, high-grade tumors or after incomplete resection, while perioperative chemotherapy may be considered for high-risk cases. In oligometastatic disease, combining local and systemic therapies is an option. Anthracycline-based chemotherapy is the first-line treatment in advanced disease, though other drugs show efficacy in certain subtypes. Given the limited options, enrolling in clinical trials is advised for patients needing further treatment.

Clinical & Translational OncologyVol. 27(4)
Hospital General Universitario Gregorio Marañón (ES), Hospital de Basurto (ES), Biogipuzkoa Health Research Institute (ES), Hospital Universitario Miguel Servet (ES), Vall d'Hebron Hospital Universitari (ES), Hospital Universitario Fundación Jiménez Díaz (ES), Complexo Hospitalario Universitario A Coruña (ES), Hospital Universitario Virgen de la Arrixaca (ES), Hospital Universitario Son Espases (ES), Hospital Universitario Virgen del Rocío (ES)
Good health and well-being
Openalex Percentile: Top 97%
Sarcoma Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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SEOM-GEIS Spanish clinical guidelines for the management of soft‑tissue sarcomas (2024) — Nadia Hindi, Áurea Molina, et al. · Clinical & Translational Oncology (2025) | TGRS Research Map | TGRS