Di-2-Ethylhexyl Phthalate (DEHP) Toxicity: Organ-Specific Impacts and Human-Relevant Findings in Animal Models & Humans - Review

Di-2-ethylhexyl phthalate (DEHP) is considered one of the most extensively used plasticizers in polyvinyl chloride (PVC) products that include medical devices, food packaging and flooring materials. However, DEHP has been classified as an endocrine disruptor and there is a global concern regarding its effects on human and animal health. The current review seeks to summarize the existing body of literature on the toxicology of DEHP in relation to a wide variety of organ systems, including endocrine dysfunction, testicular, ovarian, renal, neurotoxic, hepatotoxic, and cardiotoxic in vivo and in vitro effects performed on animal models and humans. The review will also address the potential DEHP-replacement measures in order to limit global DEHP use and ensure a safer environment.