CircSPG21 ameliorates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells and mitigates intervertebral disc degeneration through the miR-217/SIRT1 axis and mitophagy
CircSPG21 reduces oxidative stress-induced NPMSC senescence through the miR-217/SIRT1 axis and mitophagy, providing new insights into IVDD and identifying circSPG21 as a potential therapeutic target for disc degeneration.
Authors
- You Xuan
- Liuyang chen
- Sheng Yang (ORCID: https://orcid.org/0000-0003-4992-2375)
- Yongbo Zhang (ORCID: https://orcid.org/0000-0002-8216-1371)
- Liang Zhang (ORCID: https://orcid.org/0000-0002-2279-2657)
- Rui Dai (ORCID: https://orcid.org/0009-0008-2257-5039)
- Zhengguang Li
- Hua Sun
Institutions
- Xuzhou Medical College (CN)
- Dalian Medical University (CN)
- Northern Jiangsu People's Hospital (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s13287-025-04180-1
- Citations
- 10
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 14.72
Funders
- National Natural Science Foundation of China
- “333 Project” of Jiangsu Province