Development of delayed pulmonary toxicities and transcriptional changes in pre-existing interstitial lung disease mice after partial thoracic irradiation
Delayed effects of significantly declined lung function and high mortality were observed in the sRRLI model. DAD with progressive inflammation and fibrosis in bilateral lungs contributed to severe or even fatal complications after partial thoracic irradiation. The hyperactivation of inflammatory responses was clarified during long-term pulmonary toxicities. More studies are needed to investigate potential strategies to prevent and rescue severe lung complications.
Authors
- Chunlin Shao (ORCID: https://orcid.org/0000-0001-9336-9912)
- Yuchuan Zhou (ORCID: https://orcid.org/0000-0001-9407-4024)
- Jianghong Zhang (ORCID: https://orcid.org/0000-0003-4884-6411)
- Yan Pan (ORCID: https://orcid.org/0000-0003-4307-3616)
- Kevin M. Prise (ORCID: https://orcid.org/0000-0001-6134-7946)
- Liang Zeng (ORCID: https://orcid.org/0009-0000-3012-4651)
- Xinglong Liu (ORCID: https://orcid.org/0000-0002-1215-4117)
- Shengnan Zhao (ORCID: https://orcid.org/0000-0001-6538-7996)
- Yaping Xu (ORCID: https://orcid.org/0009-0003-6621-0182)
- Jiamei Fu
Institutions
- Tongji University (CN)
- Queen's University Belfast (GB)
- Shanghai Medical College of Fudan University (CN)
- Shanghai Pulmonary Hospital (CN)
Publication Details
- Journal
- Radiation Oncology
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s13014-025-02596-w
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fudan University
- Shanghai Pulmonary Hospital