Design Key Points of High-Performance Diffuse Reflectance Optical Sensors for Non-Invasive Blood Glucose Measurement

Optical sensors serve as pivotal components in the realm of non-invasive blood glucose measurement (NBGM) devices, where their efficacy directly influences the detection of weak glucose signals. This research introduces three fundamental design key points tailored for diffuse reflectance optical sensors employed for NBGM: depth resolution, detection signal-to-noise ratio, and human-sensor interface coupling. Guided by these design key points, we presented feasible design proposals for near-infrared diffuse reflectance sensors operating in the range of 1000-1700 nm. As an example, a sensor composed of five-ring detectors with a ring-shaped mask were made and tested on human skin. The innovative sensor developed herein holds promising potential for NBGM.