Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic behavioral variant frontotemporal degeneration
Overall, this integrative transcriptomic approach identified several new shared and disparate genes associated with regional vulnerability with increased biological interpretation including overlap with synaptic density maps and pathologically-specific gene expression. These findings illuminated the intricate molecular underpinnings contributing to the heterogeneous nature of disease distribution in bvFTD with distinct genetic backgrounds.
Authors
- Ting Shen (ORCID: https://orcid.org/0000-0002-3937-4427)
- Jeffrey S. Phillips (ORCID: https://orcid.org/0000-0003-0079-9441)
- Corey T. McMillan (ORCID: https://orcid.org/0000-0002-7581-6405)
- Vivianna M. Van Deerlin (ORCID: https://orcid.org/0000-0002-7400-9097)
- EunRan Suh
- Lauren Massimo (ORCID: https://orcid.org/0000-0002-3407-7335)
- Edward B. Lee (ORCID: https://orcid.org/0000-0002-4589-1180)
- Laynie Dratch (ORCID: https://orcid.org/0000-0002-2179-3199)
- David J. Irwin (ORCID: https://orcid.org/0000-0002-5599-5098)
- Jacob W. Vogel (ORCID: https://orcid.org/0000-0001-6394-9940)
Institutions
- Lund University (SE)
- Science for Life Laboratory (SE)
- University of Pennsylvania (US)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s13024-025-00806-3
- Citations
- 2
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Foundation for the National Institutes of Health