Decoding SFRP2 progenitors in sustaining tooth growth at single-cell resolution
Our study reveals a previously unrecognized subset of dental mesenchymal stem cells critical for tooth growth. This distinct subset, evolutionarily conserved between humans and mice, provides valuable insights into translational approaches for dental tissue regeneration and repair.
Authors
- Zhengwen An (ORCID: https://orcid.org/0000-0003-0360-7388)
- Qing Zhong (ORCID: https://orcid.org/0000-0001-6979-955X)
- Tianmeng Sun (ORCID: https://orcid.org/0000-0003-2261-4532)
- Xiaoyi Yu (ORCID: https://orcid.org/0000-0002-0263-4715)
- Zequn Sun (ORCID: https://orcid.org/0000-0003-4177-9199)
- Tianyuan Zhao (ORCID: https://orcid.org/0000-0002-7104-6394)
Institutions
- Jilin University (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s13287-025-04190-z
- Citations
- 5
- Primary Topic
- dental development and anomalies
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- National Natural Science Foundation of China
- Jilin University
- National Key Research and Development Program of China