MSCs with upregulated lipid metabolism block hematopoietic stem cell differentiation via exosomal CTP-1A in MDS
We suggest that the MDS BM microenvironment disrupts MSCs metabolism by increasing the expression of CPT-1A, which impairs the ability to support normal HSCs. Interestingly, the suppressive effect is mediated by exosomes rich in CPT-1A, which derived from MSCs. These findings provide novel insights into MDS MSCs-metabolism-Exosome axis in ineffective hematopoiesis and offer new strategies for the treatment of MDS.
Authors
- Chunlai Yin (ORCID: https://orcid.org/0000-0002-3040-5012)
- Jing Liu (ORCID: https://orcid.org/0009-0007-5462-2357)
- Zilong Wang (ORCID: https://orcid.org/0000-0002-6760-1471)
- Weiping Li (ORCID: https://orcid.org/0000-0002-1843-9906)
- Cheng Zhang (ORCID: https://orcid.org/0000-0003-3843-1562)
- Xia Li
- Jiaqing Liu (ORCID: https://orcid.org/0000-0001-8600-8932)
- Jinyi Ren
- Xue Yan
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s13287-025-04154-3
- Citations
- 7
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 12.39
Funders
- National Natural Science Foundation of China
- Doctoral Start-up Foundation of Liaoning Province
- Dalian Medical University