Exosomes derived from liver failure patients’ plasma stimulated mesenchymal stem cells alleviate acute liver failure
The biological effects of Exos were improved after stimulation with plasma from patients with liver failure. LF-Exos may inhibit the activity of the NLRP3 inflammasome and activate the PI3K-AKT signaling pathway to exert protective effects on acutely injured hepatocytes and a mouse model of ALF.
Authors
- Zhuoran Wang (ORCID: https://orcid.org/0009-0004-0456-6105)
- Shaoli You (ORCID: https://orcid.org/0000-0001-8689-8509)
- Bing Zhu (ORCID: https://orcid.org/0000-0003-0190-6384)
- Jun Ling
Institutions
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s13287-025-04163-2
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Science and Technology Major Project
- National Key Transform Program