Characterization of gene expression profiles in Alzheimer’s disease and osteoarthritis: A bioinformatics study
This study suggests that AD and OA shares common molecular mechanisms. The identification of EFEMP2, GABARAPL1, and TSPO as key target genes highlights potential common factors in both diseases. Further investigation into these findings could lead to new candidate targets and treatment directions for AD and OA, offering promising avenues for developing more effective and targeted therapeutic interventions.
Authors
- Jinpu Peng
- Weitian Yan
- Jiayan Shen (ORCID: https://orcid.org/0000-0002-0144-9067)
- Dewen Mao (ORCID: https://orcid.org/0000-0001-9438-9325)
- Zining Peng (ORCID: https://orcid.org/0000-0003-3081-5967)
- Nian Liu (ORCID: https://orcid.org/0000-0002-7726-9732)
- Xiaoyu Zhang (ORCID: https://orcid.org/0000-0002-2041-9955)
- Zhaofu Li (ORCID: https://orcid.org/0000-0001-7414-3707)
- Fanyu Meng
- Yuanbo Huang
- Qian Deng
Institutions
- Yunnan University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1371/journal.pone.0316708
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Yunnan Provincial Department of Education Science Research Fund Project