Deficiency of adenosine deaminase 2 skews adaptive immune repertoires toward specific sets of T- and B-cell receptors
Our findings underscore the significant influence of ADA2 on the adaptive immune system, which results in a highly specific immunogenetic signature in patients with DADA2.
Authors
- Paul Schmidt-Barbo (ORCID: https://orcid.org/0009-0008-0871-7555)
- Lisa Paschold (ORCID: https://orcid.org/0000-0003-0020-1315)
- Ivona Aksentijevich (ORCID: https://orcid.org/0000-0002-6564-7214)
- Daniel L. Kastner (ORCID: https://orcid.org/0000-0001-7188-4550)
- Christoph Schultheiß (ORCID: https://orcid.org/0000-0001-9789-5776)
- Mascha Binder (ORCID: https://orcid.org/0000-0003-0663-3004)
- Rafael Mikolajczyk (ORCID: https://orcid.org/0000-0003-1271-7204)
- A R Behn
- Carl Esperanzate
Institutions
- National Institutes of Health (US)
- University Hospital of Basel (CH)
- National Human Genome Research Institute (US)
- Martin Luther University Halle-Wittenberg (DE)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1016/j.jaci.2025.01.032
- Citations
- 1
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.12