Carnosinase inhibition enhances reactive species scavenging in high fat diet
Our findings suggest that inhibition of carnosinase enzymes can increase the life-span, and thereby enhance the efficacy, of endogenous carnosine in vivo, thereby offering potential therapeutic benefits against obesity and other cardiometabolic diseases characterised by metabolic stress.
Authors
- Vivian K Lee
- Paul Caton (ORCID: https://orcid.org/0000-0003-0902-0676)
- John D. Wallis (ORCID: https://orcid.org/0000-0001-7259-8783)
- A. Christopher Garner (ORCID: https://orcid.org/0000-0003-2488-0623)
- Suniya Khatun
- Charlie A. Lavilla (ORCID: https://orcid.org/0000-0002-9832-1229)
- Sreya Bhattacharya
- Merell P. Billacura (ORCID: https://orcid.org/0000-0002-4398-8130)
- Mark D. Turner (ORCID: https://orcid.org/0000-0001-7175-1053)
- Craig Sale (ORCID: https://orcid.org/0000-0002-5816-4169)
- Daniel P. Cotton
Institutions
- Manchester Metropolitan University (GB)
- English Institute of Sport (GB)
- King's College London (GB)
- King's College School (GB)
- Nottingham Trent University (GB)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1016/j.lfs.2025.123448
- Citations
- 1
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- British Council