Increased macrophages contribute to thyroid hormone‐induced cardiac alterations in mice
Together, these new findings indicate the involvement of macrophages in the cardiac changes promoted by higher T3 levels. Considering that sustained cardiac growth and tachycardia can potentially lead to heart failure, our results suggest that targeting macrophages might be a novel therapeutic approach for attenuating cardiac disorders caused by hyperthyroidism.
Authors
- Gabriela Placoná Diniz (ORCID: https://orcid.org/0000-0003-1278-4431)
- Gabriela Cavazza Cerri (ORCID: https://orcid.org/0000-0002-1975-7420)
- José Maria Álvarez Mosig
- Maria Cláudia Irigoyen (ORCID: https://orcid.org/0000-0003-2097-3662)
- Maria Regina D’Império Lima (ORCID: https://orcid.org/0000-0002-4683-7709)
- Nathalia Senger (ORCID: https://orcid.org/0000-0002-9410-1050)
- Tim Christian Kuhn (ORCID: https://orcid.org/0000-0003-2357-1335)
- Gislane de Almeida Santos (ORCID: https://orcid.org/0000-0002-9605-2061)
- Maria Luiza Morais Barreto‐Chaves (ORCID: https://orcid.org/0000-0001-5514-7921)
- Florian Leuschner (ORCID: https://orcid.org/0000-0003-1157-474X)
- Aline Cristina Parletta (ORCID: https://orcid.org/0000-0003-4316-0218)
- Denival Nascimento Vieira‐Junior
- D. Souza (ORCID: https://orcid.org/0009-0001-9370-8686)
- J.S. Xavier
- Rogério Silva do Nascimento (ORCID: https://orcid.org/0000-0003-2757-9238)
- Joice Silva Mota
Institutions
- Carter Center (US)
- Universidade de São Paulo (BR)
- Heidelberg University (DE)
- University of South Florida (US)
- University Hospital Heidelberg (DE)
- University of Virginia (US)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1111/apha.70011
- Citations
- 1
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico