Fibrinogen levels and bleeding risk in adult extracorporeal cardiopulmonary resuscitation: multicenter observational study subanalysis
•Hypofibrinogenemia frequently occurs in extracorporeal cardiopulmonary resuscitation (ECPR) and may heighten bleeding risk. This subanalysis of a multicenter observational study (SAVE-J II) included 2,100 adult patients receiving ECPR after out-of-hospital cardiac arrest at 36 facilities in Japan.•Overall, 7.5% of patients experienced non-cannulation hemorrhagic complications, and those with fibrinogen levels below 140 mg/dL at ECPR initiation faced significantly higher bleeding risk. These findings underscore the importance of monitoring and managing fibrinogen levels in ECPR to mitigate hemorrhagic events and improve patient outcomes.
Authors
- Tetsuya Sakamoto (ORCID: https://orcid.org/0000-0002-5070-4343)
- Tetsumei Urano (ORCID: https://orcid.org/0000-0002-7398-9732)
- Yoshihiro Tanaka (ORCID: https://orcid.org/0000-0002-0300-7924)
- Yasuhiro Kuroda (ORCID: https://orcid.org/0000-0002-8448-7965)
- Eiji Nakatani (ORCID: https://orcid.org/0000-0002-4876-446X)
- Hatoko Sasaki (ORCID: https://orcid.org/0000-0002-5785-0482)
- Toru Hifumi (ORCID: https://orcid.org/0000-0003-3581-0890)
- Seiya Kanou
- Akihiko Inoue (ORCID: https://orcid.org/0000-0002-9627-3702)
Institutions
- Nagoya City University (JP)
- Kobe Medical Center (JP)
- St. Luke's International Hospital (JP)
- Kagawa University Hospital (JP)
- Fujieda Municipal General Hospital (JP)
- Teikyo University (JP)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.rpth.2025.102700
- Citations
- 2
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 1.35