Effects of melatonin supplementation on oxidative stress, and inflammatory biomarkers in diabetic patients with chronic kidney disease: a double-blind, randomized controlled trial
Our study showed that melatonin supplementation did not significantly affect oxidative stress or inflammatory markers, including TAC, TOS, MDA, IL-6, and hs-CRP, in diabetic patients with CKD. Despite a decrement in TOS, MDA, IL-6, and hs-CRP levels after 10 weeks, this was not statistically significant. Further studies with larger sample sizes, greater dosages, and longer follow-up periods are recommended.
Authors
- Hamed Mohammadi (ORCID: https://orcid.org/0000-0003-2046-7356)
- Monir Sadat Hakemi (ORCID: https://orcid.org/0000-0002-0602-6557)
- Ahmed Niri (ORCID: https://orcid.org/0000-0002-6743-1628)
- Hossein Imani (ORCID: https://orcid.org/0000-0001-5297-9941)
- Fatemeh Naeini (ORCID: https://orcid.org/0000-0003-1833-743X)
- Amir Ahmad Nassiri (ORCID: https://orcid.org/0000-0002-7339-0965)
- Sara Sadeghi (ORCID: https://orcid.org/0000-0002-1657-1487)
- Fatemeh Hosseini (ORCID: https://orcid.org/0000-0002-3843-7692)
- Fatemeh Pourrezagholie
Institutions
- University of Tehran (IR)
- Shariati Hospital (IR)
- Imam Hossein Hospital (IR)
- Shahid Beheshti University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- BMC Nutrition
- Published
- 2025-02-08
- DOI
- https://doi.org/10.1186/s40795-025-01026-0
- Citations
- 4
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 3.66
Funders
- Tehran University of Medical Sciences and Health Services