Inhibiting HSP90 changes the expression pattern of PINK1 and BNIP3 and induces oxidative stress in colon cancer cells
Targeting HSP90 in colon cancer cells disrupts their survival by decreasing PINK1 and increasing BNIP3, which activates oxidative and endoplasmic reticulum stress, ultimately triggering apoptosis.
Authors
- Ejlal Abu‐El‐Rub
- Fatimah Almahasneh (ORCID: https://orcid.org/0000-0002-8799-2721)
- Ayman Alzu’bi
- Ala A. Aldamen
- Amal Al‐Omari (ORCID: https://orcid.org/0000-0001-7571-3097)
- Raed M. Al‐Zoubi (ORCID: https://orcid.org/0000-0002-0548-429X)
- Ramada R. Khaswaneh
- Rawan Almazari (ORCID: https://orcid.org/0009-0001-5133-0945)
- Heba F. AI-jariri
- Tuqa Yousef
- Amani Kasasbeh
Institutions
- Jordan University of Science and Technology (JO)
- Hamad Medical Corporation (QA)
- Qatar University (QA)
- Yarmouk University (JO)
Publication Details
- Journal
- Molecular Biology Reports
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1007/s11033-025-10303-x
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hamad Medical Corporation
- Yarmouk University
- Qatar National Library