Mechanoredox-Enabled Isothiocyanation of Primary Amines Using Piezoelectric Material as the Redox Catalyst
A novel mechanoredox-enabled synthesis of aromatic and aliphatic isothiocyanates from primary amines and carbon disulfide under ball milling conditions using a piezoelectric material (BaTiO<sub>3</sub>) as the redox catalyst has been developed. This method displays several features, such as short reaction time, operational simplicity, room temperature and air conditions, minimal solvent, broad substrate scope, and recyclable cheap catalyst. Preliminary mechanistic studies revealed that highly polarized piezoelectric material acted as a single-electron transfer (SET) oxidation reagent for the key desulfurization process.
Authors
- Jia‐Chen Xiang (ORCID: https://orcid.org/0000-0003-2422-6103)
- Huiying Ren (ORCID: https://orcid.org/0000-0002-5545-5470)
- Miao Wang (ORCID: https://orcid.org/0009-0003-5143-7448)
- Xiao‐Yu Pu
- Shan Jiang (ORCID: https://orcid.org/0000-0003-4136-8285)
- Xiaolu Zhang (ORCID: https://orcid.org/0009-0001-6967-6987)
- Bang‐Tun Zhao
- He-Ying Zhu
Institutions
- Zhengzhou University (CN)
- Luoyang Normal University (CN)
- Southeast University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1021/acs.joc.4c02526
- Citations
- 2
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Natural Science Foundation of Henan Province
- Henan Provincial Science and Technology Research Project