Can nebulised heparin reduce acute lung injury in patients with SARS‑CoV‑2 requiring advanced respiratory support in Ireland: the CHARTER‑Ireland phase Ib/IIa, randomised, parallel-group, open-label study

Nebulised unfractionated heparin was safe and well tolerated, but did not reduce D-dimer concentrations, and worsened oxygenation indices in patients with COVID-19 ARDS.

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Publication Details

Journal
Intensive Care Medicine Experimental
Published
2025-02-07
DOI
https://doi.org/10.1186/s40635-025-00727-x
Citations
4
Primary Topic
COVID-19 Clinical Research Studies
Type
article
Field-Weighted Citation Impact
5.58

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article

Can nebulised heparin reduce acute lung injury in patients with SARS‑CoV‑2 requiring advanced respiratory support in Ireland: the CHARTER‑Ireland phase Ib/IIa, randomised, parallel-group, open-label study

Camilla Giacomini, Frank M.P. van Haren, Shane McGeary, Daniel O’Toole et al.
4 citations
Intensive Care Medicine Experimental
COVID-19 Clinical Research Studies
5.58
article

Can nebulised heparin reduce acute lung injury in patients with SARS‑CoV‑2 requiring advanced respiratory support in Ireland: the CHARTER‑Ireland phase Ib/IIa, randomised, parallel-group, open-label study

Camilla Giacomini, Frank M.P. van Haren, Shane McGeary, Daniel O’Toole, John Robert Sheehan, Alberto Alvarez‐Iglesias, M Fitzgerald, Catriona Cody, David Cosgrave, Pádraig Calpin, Bairbre McNicholas, Gerard F. Curley, Claire Masterson, Barry Dixon, Ciara Hanley, John Ferguson, Darragh Murphy, Maeve Kernan, John G. Laffey, Roger Smith, Marion Murphy, Christine Greene
article en
4 citations

Abstract

Nebulised unfractionated heparin was safe and well tolerated, but did not reduce D-dimer concentrations, and worsened oxygenation indices in patients with COVID-19 ARDS.

Intensive Care Medicine ExperimentalVol. 13(1)
Australian National University (AU), Royal College of Surgeons in Ireland (IE), Ollscoil na Gaillimhe – University of Galway (IE), Connolly Hospital Blanchardstown (IE), Beaumont Hospital (IE), University Hospital Galway (IE), University Hospital Limerick (IE), St Vincent's Hospital Melbourne (AU), St George Hospital (AU)
Science Foundation Ireland
Good health and well-being
Openalex Percentile: Top 5%
COVID-19 Clinical Research Studies
5.58
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