Can nebulised heparin reduce acute lung injury in patients with SARS‑CoV‑2 requiring advanced respiratory support in Ireland: the CHARTER‑Ireland phase Ib/IIa, randomised, parallel-group, open-label study
Nebulised unfractionated heparin was safe and well tolerated, but did not reduce D-dimer concentrations, and worsened oxygenation indices in patients with COVID-19 ARDS.
Authors
- Camilla Giacomini
- Frank M.P. van Haren (ORCID: https://orcid.org/0000-0001-8037-4229)
- Shane McGeary
- Daniel O’Toole (ORCID: https://orcid.org/0000-0001-5422-8711)
- John Robert Sheehan (ORCID: https://orcid.org/0000-0002-2078-5752)
- Alberto Alvarez‐Iglesias (ORCID: https://orcid.org/0000-0001-5011-9008)
- M Fitzgerald
- Catriona Cody
- David Cosgrave (ORCID: https://orcid.org/0000-0002-5069-0201)
- Pádraig Calpin (ORCID: https://orcid.org/0000-0003-3278-3567)
- Bairbre McNicholas (ORCID: https://orcid.org/0000-0001-9524-4021)
- Gerard F. Curley (ORCID: https://orcid.org/0000-0003-0271-195X)
- Claire Masterson (ORCID: https://orcid.org/0000-0002-9863-5324)
- Barry Dixon (ORCID: https://orcid.org/0000-0002-5151-1674)
- Ciara Hanley (ORCID: https://orcid.org/0000-0001-6033-6786)
- John Ferguson (ORCID: https://orcid.org/0000-0001-6609-2073)
- Darragh Murphy (ORCID: https://orcid.org/0009-0001-1443-5166)
- Maeve Kernan
- John G. Laffey (ORCID: https://orcid.org/0000-0002-1246-9573)
- Roger Smith (ORCID: https://orcid.org/0000-0002-9356-2285)
- Marion Murphy
- Christine Greene
Institutions
- Australian National University (AU)
- Royal College of Surgeons in Ireland (IE)
- Ollscoil na Gaillimhe – University of Galway (IE)
- Connolly Hospital Blanchardstown (IE)
- Beaumont Hospital (IE)
- University Hospital Galway (IE)
- University Hospital Limerick (IE)
- St Vincent's Hospital Melbourne (AU)
- St George Hospital (AU)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s40635-025-00727-x
- Citations
- 4
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- Science Foundation Ireland