Metal/Peroxide‐Free [5 + 1] Cyclization of 2‐Vinylanilines with <i>tert</i> ‐Butyl Nitrite to Access Diverse Cinnolines
Abstract An efficient metal/peroxide‐free [5 + 1] cyclization of 2‐vinylanilines with TBN was realized to access various cinnolines with high yields. In addition, benzo[ e ]pyrrolo[2,1‐c][1,2,4]triazines could also be obtained by using 2‐(1 H ‐pyrrol‐1‐yl)anilines as the raw materials. This cascade system selected common/low‐cost tert ‐butyl nitrite as the N1 source, which performed broad substrate scopes/simple operation/mild conditions/available scaled up to 1 mmol.
Authors
- Zejiang Li (ORCID: https://orcid.org/0000-0001-9579-9895)
- Zexuan Liu
- Huaqing Liu (ORCID: https://orcid.org/0000-0002-5248-4655)
- Lijun Li (ORCID: https://orcid.org/0000-0003-2966-6992)
- Qinqin Yan
- Yanzhao Zeng
Institutions
- Hebei University (CN)
Publication Details
- Journal
- ChemistrySelect
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/slct.202405578
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hebei Province
- Hebei University