Transcriptional and Neurochemical Signatures of Cerebral Blood Flow Alterations in Individuals With Schizophrenia or at Clinical High Risk for Psychosis
Our findings underscore the value of integrating multiscale data as a promising hypothesis-generating approach toward decoding biological pathways involved in neuroimaging-based psychosis phenotypes, potentially guiding novel interventions.
Authors
- Oliver Howes (ORCID: https://orcid.org/0000-0002-2928-1972)
- Gemma Modinos (ORCID: https://orcid.org/0000-0002-7870-066X)
- Ilaria Bonoldi
- Justine Y. Hansen (ORCID: https://orcid.org/0000-0003-3142-7480)
- Mathilde Antoniades (ORCID: https://orcid.org/0000-0002-8241-835X)
- Yashar Zeighami (ORCID: https://orcid.org/0000-0002-0583-5811)
- Daniel Martins (ORCID: https://orcid.org/0000-0002-0239-8206)
- Fernando Zelaya (ORCID: https://orcid.org/0000-0002-9525-1560)
- Owen O’Daly (ORCID: https://orcid.org/0000-0001-5690-1252)
- Leyla Abbasova (ORCID: https://orcid.org/0000-0003-0206-9506)
- Matthijs G. Bossong (ORCID: https://orcid.org/0000-0001-7880-2300)
- Samuel Knight (ORCID: https://orcid.org/0000-0003-3420-3722)
- Paul Allen (ORCID: https://orcid.org/0000-0002-4924-4730)
- Alice Egerton (ORCID: https://orcid.org/0000-0003-2939-064X)
- Thomas T. Liu (ORCID: https://orcid.org/0000-0002-1978-7486)
- Matilda Azis (ORCID: https://orcid.org/0000-0001-8164-0357)
- Ottavia Dipasquale (ORCID: https://orcid.org/0000-0002-2867-8222)
- Philip K. McGuire (ORCID: https://orcid.org/0000-0003-4381-0532)
- David Shin (ORCID: https://orcid.org/0000-0001-6291-5327)
Institutions
- Montreal Neurological Institute and Hospital (CA)
- University City Science Center (US)
- University of San Diego (US)
- King's College London (GB)
- General Electric (Spain) (ES)
- Douglas Mental Health University Institute (CA)
- University Medical Center Utrecht (NL)
- Olea Medical (France) (FR)
- University of California San Diego (US)
- California University of Pennsylvania (US)
- University of Oxford (GB)
- McGill University (CA)
Publication Details
- Journal
- Biological Psychiatry
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1016/j.biopsych.2025.01.028
- Citations
- 9
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 12.88
Funders
- Mental Health Research UK
- Schizophrenia Research Fund
- Wellcome Trust
- National Institute for Health and Care Research
- Department of Health and Social Care
- Royal Society
- King's College London
- NIHR Maudsley Biomedical Research Centre
- Medical Research Council