LINE-1 ORF1p Mimics Viral Innate Immune Evasion Mechanisms in Pancreatic Ductal Adenocarcinoma
This study uncovers PDAC-specific mechanisms that dampen immune responses to viral-repeat RNA via long interspersed nuclear element 1 ORF1p. Suppression of ORF1p activates antiviral responses, reducing tumor growth and epithelial-mesenchymal transition. High ORF1p expression correlates with poor prognosis, highlighting its potential as a therapeutic target for PDAC.
Authors
- Peter Richieri
- David Tsai Ting (ORCID: https://orcid.org/0000-0002-3261-2322)
- Michael J. Raabe (ORCID: https://orcid.org/0009-0009-7345-7507)
- Katherine H. Xu (ORCID: https://orcid.org/0009-0002-8688-5702)
- Joshua R. Kocher (ORCID: https://orcid.org/0009-0006-4418-9898)
- Siyu Sun (ORCID: https://orcid.org/0000-0001-8461-9609)
- Eunae You (ORCID: https://orcid.org/0000-0001-9028-4024)
- Martin S. Taylor (ORCID: https://orcid.org/0000-0001-5824-142X)
- Linda T. Nieman (ORCID: https://orcid.org/0000-0002-0141-8308)
- Natalie I. Ho (ORCID: https://orcid.org/0009-0008-1502-8520)
- Bidish K. Patel (ORCID: https://orcid.org/0000-0002-5931-1917)
- Benjamin D. Greenbaum (ORCID: https://orcid.org/0000-0001-6153-8793)
- Ildiko E. Phillips (ORCID: https://orcid.org/0000-0002-5752-998X)
- Yuhui Song (ORCID: https://orcid.org/0000-0002-5087-4684)
- Alexandra S. Rojas (ORCID: https://orcid.org/0009-0004-8875-9296)
- Patrick Danaher (ORCID: https://orcid.org/0000-0002-2844-5883)
- Paul K.S. Shin
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Bruker (United States) (US)
- Korea University (KR)
- Cornell University (US)
- Brown University (US)
- CRC for Spatial information (AU)
- Massachusetts General Hospital (US)
- Center for Cancer Research (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-1317
- Citations
- 10
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 7.18
Funders
- Massachusetts Life Sciences Center
- Pershing Square Sohn Cancer Research Alliance
- Ministry of Science and ICT, South Korea
- National Institutes of Health