Unexpected Hypotension in a Female Patient with Fabry Disease: Switching from Agalsidase α to β after Long-term ERT
Fabry disease is a rare X-linked lysosomal storage disorder. Enzyme replacement therapies (ERTs), such as agalsidase α and β, are available treatment options. While infusion-related reactions (IRRs) are known to occur at the initiation of ERT owing to immune responses, there is limited information on IRRs during long-term ERT. We report the case of a female patient with Fabry disease who developed unexpected hypotension after six years of stable treatment with agalsidase α, leading to a switch to agalsidase β. Continuous monitoring may be essential to identify potential IRRs in female patients with Fabry disease receiving long-term ERT.
Authors
- Shoji Saito (ORCID: https://orcid.org/0000-0002-8235-8086)
- Reiko Muto (ORCID: https://orcid.org/0000-0002-5562-3913)
- Naoyuki Matsuda (ORCID: https://orcid.org/0000-0001-9153-7695)
- Kazumitsu Sugiura (ORCID: https://orcid.org/0000-0002-5207-4592)
- Tetsuya Amano (ORCID: https://orcid.org/0000-0002-6833-3675)
- Yuka Sato (ORCID: https://orcid.org/0000-0002-4363-5626)
- Shoichi Maruyama (ORCID: https://orcid.org/0000-0002-8858-632X)
- Takuya Sugiura (ORCID: https://orcid.org/0009-0002-7952-4175)
- Noritoshi Kato (ORCID: https://orcid.org/0000-0003-3924-6887)
- Atsushi Numaguchi (ORCID: https://orcid.org/0000-0003-4875-6037)
- Michiko Higashi (ORCID: https://orcid.org/0000-0002-0410-2229)
- Takayuki Katsuno (ORCID: https://orcid.org/0000-0003-1555-392X)
- Kayaho Maeda
- Fumitaka Kamiya
Institutions
- Fujita Health University (JP)
- Aichi Medical University (JP)
- Handa City Hospital (JP)
- Komaki City Hospital (JP)
- Aichi Medical University Medical Center
- Nagoya University (JP)
Publication Details
- Journal
- Internal Medicine
- Published
- 2025-02-07
- DOI
- https://doi.org/10.2169/internalmedicine.4685-24
- Citations
- 3
- Primary Topic
- Lysosomal Storage Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 3.49