Duchenne Muscular Dystrophy with Extreme Emaciation and a Discrepancy between Cystatin C-based eGFR and Inulin Clearance
We describe the case of a 25-year-old male with Duchenne muscular dystrophy and acute kidney injury who was receiving mechanical ventilation. The patient's estimated glomerular filtration rate (eGFR) was assessed using formulas based on creatinine, cystatin C, and inulin levels over time during the recovery of his renal function. The creatinine-based eGFR was extremely high throughout the study period. The cystatin C-based eGFR was also higher than the inulin clearance. These findings suggest that cystatin C-based eGFR may also exceed inulin clearance in patients with an extremely reduced fat mass, in addition to a reduced muscle mass.
Authors
- Yoshifumi Ubara (ORCID: https://orcid.org/0000-0003-2322-8203)
- Naoki Sawa (ORCID: https://orcid.org/0000-0003-2092-4094)
- Makiko Takeyasu
- Keiichi Sumida
- Hiroki Mizuno (ORCID: https://orcid.org/0000-0003-4187-1067)
- Masayuki Yamanouchi (ORCID: https://orcid.org/0000-0003-3264-9691)
- Izumi Sugimoto
- Yuki Oba (ORCID: https://orcid.org/0000-0002-1494-3291)
- Takehiko Wada (ORCID: https://orcid.org/0000-0001-9740-5183)
- Noriko Inoue
- Tatsuya Suwabe (ORCID: https://orcid.org/0000-0003-0825-2512)
- Akinari Sekine (ORCID: https://orcid.org/0000-0001-7326-4988)
- Eiko Hasegawa
- Kiho Tanaka
- Shigekazu Kurihara
Institutions
- Toranomon Hospital (JP)
Publication Details
- Journal
- Internal Medicine
- Published
- 2025-02-07
- DOI
- https://doi.org/10.2169/internalmedicine.4920-24
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00