Asymmetric Construction of the Tricyclic Core Structure of Prostratin
A synthetic study on asymmetric construction of the tricyclic core structure of prostratin is developed through a convergent strategy. Critical to the success of this endeavor is the strategic use of intermolecular allylic nucleophilic substitution to assemble the ring A system and ring C system while utilizing intramolecular nucleophilic addition to close the seven-membered ring.
Authors
- Canhui Tu
- Cichang Ling (ORCID: https://orcid.org/0000-0003-1576-7792)
- Shaomin Fu (ORCID: https://orcid.org/0000-0002-7095-0672)
- Yunlong Yang (ORCID: https://orcid.org/0000-0003-1551-9828)
- Bo Liu (ORCID: https://orcid.org/0000-0002-6235-1573)
- Jiaxin Du
Institutions
- Sichuan University (CN)
- Green Chemistry (PL)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1021/acs.orglett.4c03606
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Department of Science and Technology of Sichuan Province
- Fundamental Research Funds for the Central Universities