The value of ITGA and ITGB superfamily genes as biomarkers for the early diagnosis and prognosis of gliomas: A retrospective observational study based on the GEPIA and CGGA databases

Glioma is one of the most common primary malignant tumors of the central nervous system, with a poor prognosis and easy recurrence after surgery. Exploring potential biomarkers is highly important for early detection, diagnosis, and disease evaluation. Abnormal expression of integrins is closely related to tumor metastasis, promoting both tumor metastasis and angiogenesis through intracellular signaling pathways. In this study, the expression levels of ITGA and ITGB superfamily genes in glioma was obtained from the GEPIA and CGGA databases, and the differences in their expression between tumor and normal tissues were compared. Combined with the known tumor marker IDH, correlations were analyzed to explore the relationships between the expression levels of ITGA and ITGB superfamily genes and patient prognosis. These results suggest that ITGA3, ITGA5, ITGB5, and ITGB8 are highly expressed in glioblastoma and could be used as potential biomarkers. In low-grade gliomas, the expressions of ITGA6, ITGB1, ITGB2, ITGB5, and ITGB8 were significantly increased, which could be used as biomarkers. In early gliomas, ITGA3, ITGA5, ITGB1, ITGB2, ITGB5, and ITGB8 are highly expressed in patients with IDH wild-type glioma,and the prognosis is good. Therefore, these genes can be used as early biomarkers. These findings indicate that the expression of ITGA and ITGB superfamily genes, as biomarkers, has important clinical significance in the grading, diagnosis and prognostic analysis of glioma. ITG superfamily genes as biomarkers for the diagnosis and prognosis of gliomas (By Figdraw).