Ceftriaxone population pharmacokinetics in plasma and cerebrospinal fluid of neurocritical care patients
High attainment of plasma target exposures was achieved with higher than standard dosing. Dosing recommendations to optimise targeted CSF ceftriaxone exposures for treatment of ventriculitis could not be made given inadequate model predictability.
Authors
- Therese Starr (ORCID: https://orcid.org/0000-0002-8312-4898)
- Menino Osbert Cotta
- Jason A. Roberts (ORCID: https://orcid.org/0000-0001-6218-435X)
- Steven C. Wallis (ORCID: https://orcid.org/0000-0002-2392-9854)
- Jeffrey Lipman (ORCID: https://orcid.org/0000-0002-5965-9876)
- Aaron J. Heffernan
- Amelia Livermore
- Suzanne L. Parker (ORCID: https://orcid.org/0000-0002-6124-7475)
- Gavin M. Joynt (ORCID: https://orcid.org/0000-0002-5823-3435)
- Nilesh Kumta
- Xin Liu (ORCID: https://orcid.org/0000-0002-6210-8100)
- Wong Tat Wai
Institutions
- The University of Queensland (AU)
- Chinese University of Hong Kong (HK)
- Royal Brisbane and Women's Hospital (AU)
Publication Details
- Journal
- International Journal of Antimicrobial Agents
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1016/j.ijantimicag.2025.107461
- Citations
- 1
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 1.39