Epigenetic Control of an Auxiliary Subunit of Voltage-Gated Sodium Channels Regulates the Strength of Drug-Cue Associations and Relapse-Like Cocaine Seeking
Our findings suggest that HDAC5's control of NAc Scn4b expression governs the formation of cocaine-cue, but not sucrose-cue, associations through modulation of NAc MSN intrinsic excitability and drug-induced NAc plasticity mechanisms.
Authors
- Rose Marie Akiki (ORCID: https://orcid.org/0000-0001-8141-5344)
- Tsvetkov Ea (ORCID: https://orcid.org/0000-0002-6784-0907)
- Susana Comte‐Walters
- Makoto Taniguchi (ORCID: https://orcid.org/0000-0001-6356-2463)
- Christopher W. Cowan (ORCID: https://orcid.org/0000-0001-5472-3296)
- Colin L. Welsh (ORCID: https://orcid.org/0000-0001-9808-0835)
- Lauren E. Ball (ORCID: https://orcid.org/0000-0001-6780-1679)
- Lalima K. Madan (ORCID: https://orcid.org/0000-0002-3839-4936)
- D.J. Wood (ORCID: https://orcid.org/0000-0002-1841-3706)
- Rachel D. Penrod (ORCID: https://orcid.org/0000-0001-9752-2128)
- Ethan M. Anderson (ORCID: https://orcid.org/0000-0002-4021-6741)
- Timothy G. Wood
- Michelle Bloyd
Institutions
- Medical University of South Carolina (US)
- National Student Clearinghouse Research Center (US)
Publication Details
- Journal
- Biological Psychiatry
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1016/j.biopsych.2025.01.027
- Citations
- 5
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 4.55
Funders
- University of South Carolina
- National Institutes of Health
- National Institute on Drug Abuse
- National Institute of General Medical Sciences